1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide Y320
1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxami
CAS: 288250-47-5
Molecular Formula: C27H29ClN6O2
1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide Y320 - Names and Identifiers
1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide Y320 - Physico-chemical Properties
| Molecular Formula | C27H29ClN6O2 |
| Molar Mass | 505.01 |
| Density | 1.34±0.1 g/cm3(Predicted) |
| Boling Point | 631.2±55.0 °C(Predicted) |
| pKa | 11.82±0.70(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | Y-320 murine CD4 T cells stimulated by IL-15, CXCL12, and anti-CD3 mAb also inhibited IFN-γ and TNF-α production. Y-320 murine CD4 T cells stimulated by IL-15, CXCL12, and anti-CD3 mAb also inhibited IFN-γ and TNF-α production. |
| In vivo study | Y-320 (0.3-3 mg/kg, P. O.) improves collagen-induced arthritis (CIA) in mice, reduces IL-17 mRNA in arthritic joints, and exhibits therapeutic effects on CIA in rhesus monkeys. In addition, Y-320 combined with anti-TNF-α mAb showed a synergistic effect on chronic CIA in mice. Y-320 (0.3-3 mg/kg, P. O.) improves collagen-induced arthritis (CIA) in mice, reduces IL-17 mRNA in arthritic joints, and in rhesus monkeys showed therapeutic effect on CIA. In addition, Y-320 combined with anti-TNF-α mAb showed a synergistic effect on chronic CIA in mice. |
1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide Y320 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.98 ml | 9.901 ml | 19.802 ml |
| 5 mM | 0.396 ml | 1.98 ml | 3.96 ml |
| 10 mM | 0.198 ml | 0.99 ml | 1.98 ml |
| 5 mM | 0.04 ml | 0.198 ml | 0.396 ml |
Last Update：2024-01-02 23:10:35
1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide Y320 - Introduction
1-(4-chloryl)-N-(3-cyano-4-(chloryl) phenyl)-is a commonly used chemical reagent whose chemical name is sodium methylpropionate. The following is a description of the properties, uses, preparation and safety information of 1-(4-Chlorophenyl)-N-(3-cyano-4-(3-chlorophenyl):
Nature:
1-(4-Chlorophenyl)-N-(3-cyano-4-() phenyl)-is a colorless crystalline solid, soluble in water and ethanol. Its chemical structure is CH3CH(CH3)COONa. 1-(4-chloryl)-N-(3-cyano-4-(phenyl))-phenyl is odorless, alkaline and has a low melting point.
Use:
1-(4-chroophenyl)-N-(3-cyano-4-() phenyl)-is widely used in chemical experiments, synthetic reactions, pharmaceutical production and some industrial processes. It can be used as a neutral or basic catalyst to catalyze esterification of esters and other alkyd reactions. Furthermore, 1-(4-chroophenyl)-N-(3-cyano-4-(Loryl) phenyl)-is also useful as a curing agent, feed additive and as a dye auxiliary in the textile industry.
Preparation Method:
The preparation of 1-(4-Chlorophenyl)-N-(3-cyano-4-() phenyl)-is obtained by reacting 2-methylpropionic acid with sodium hydroxide. An appropriate amount of 2-methylpropionic acid is first dissolved in water and then sodium hydroxide solution is added. Under stirring and cooling conditions, crystals of 1-(4-Chlorophenyl)-N-(3-cyano-4-() phenyl)-calcium are precipitated, which can be filtered and dried to give the final product.
Safety Information:
The following safety precautions should be taken when using 1-(4-chroophenyl)-N-(3-cyano-4-(3-cyano-4)-phenyl)-phenyl:
-Use personal protective equipment, gloves and goggles when touching 1-(4-cyano-4)-N-(3-cyano-4-(such as phenyl)), to avoid direct contact with skin and eyes.
-Avoid inhaling 1-(4-Chlorophenyl)-N-(3-cyanyl)-phenyl dust or solution, ventilation should be provided or operated in a well-ventilated area.
- 1-(4-chroophenyl)-N-(3-cyano-4-(4-chroophenyl)-phenyl is an alkaline substance that may cause irritation to the skin and eyes. If contact occurs, rinse immediately with plenty of water and seek medical help.
-Avoid mixing, storing or handling with strong oxidants and flammable substances to prevent dangerous reactions.
-Maintain the tightness of 1-(4-chroophenyl)-N-(3-cyano-4-() phenyl)-during storage and transportation, and avoid humidity and high temperature environment.
Please note that the information provided here is for reference only, using 1-(4-chroophenyl)-N-(3-cyano-4-(phenyl) phenyl)-Chemical safety guidelines should be followed and professional advice should be consulted when necessary.
Nature:
1-(4-Chlorophenyl)-N-(3-cyano-4-() phenyl)-is a colorless crystalline solid, soluble in water and ethanol. Its chemical structure is CH3CH(CH3)COONa. 1-(4-chloryl)-N-(3-cyano-4-(phenyl))-phenyl is odorless, alkaline and has a low melting point.
Use:
1-(4-chroophenyl)-N-(3-cyano-4-() phenyl)-is widely used in chemical experiments, synthetic reactions, pharmaceutical production and some industrial processes. It can be used as a neutral or basic catalyst to catalyze esterification of esters and other alkyd reactions. Furthermore, 1-(4-chroophenyl)-N-(3-cyano-4-(Loryl) phenyl)-is also useful as a curing agent, feed additive and as a dye auxiliary in the textile industry.
Preparation Method:
The preparation of 1-(4-Chlorophenyl)-N-(3-cyano-4-() phenyl)-is obtained by reacting 2-methylpropionic acid with sodium hydroxide. An appropriate amount of 2-methylpropionic acid is first dissolved in water and then sodium hydroxide solution is added. Under stirring and cooling conditions, crystals of 1-(4-Chlorophenyl)-N-(3-cyano-4-() phenyl)-calcium are precipitated, which can be filtered and dried to give the final product.
Safety Information:
The following safety precautions should be taken when using 1-(4-chroophenyl)-N-(3-cyano-4-(3-cyano-4)-phenyl)-phenyl:
-Use personal protective equipment, gloves and goggles when touching 1-(4-cyano-4)-N-(3-cyano-4-(such as phenyl)), to avoid direct contact with skin and eyes.
-Avoid inhaling 1-(4-Chlorophenyl)-N-(3-cyanyl)-phenyl dust or solution, ventilation should be provided or operated in a well-ventilated area.
- 1-(4-chroophenyl)-N-(3-cyano-4-(4-chroophenyl)-phenyl is an alkaline substance that may cause irritation to the skin and eyes. If contact occurs, rinse immediately with plenty of water and seek medical help.
-Avoid mixing, storing or handling with strong oxidants and flammable substances to prevent dangerous reactions.
-Maintain the tightness of 1-(4-chroophenyl)-N-(3-cyano-4-() phenyl)-during storage and transportation, and avoid humidity and high temperature environment.
Please note that the information provided here is for reference only, using 1-(4-chroophenyl)-N-(3-cyano-4-(phenyl) phenyl)-Chemical safety guidelines should be followed and professional advice should be consulted when necessary.
Last Update：2024-04-09 19:05:02
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Product Name: 1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxami Visit Supplier Webpage Request for quotation
CAS: 288250-47-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 288250-47-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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